Control №1 of pharmaceutical chemistry

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a) processes and devices in the technology of pharmaceutical manufacture powders and fees

1. Describe the process of grinding hard materials - (definition, purpose and types, the degree of grinding.)

a. How does the particle size on the bioavailability and the therapeutic efficacy of medicines

b. Give an example of LF with varying degrees of dispersion LP for comparison.

2. What is the basis of the theory of shredding summarized volume and surface of the hypothesis and the theory of Rehbinder. The basic rule of grinding. Employment grinding.

3. pulverizer (crusher and mill) shows the classification and comparative description.

Fill in the table:

4. List the LF, which is used in the manufacture of grinding.

Fill in the table:

5. What is the shredded material (as a concept in the CFT)?

6. What are the principles laid down in the classifications of the ground material

7. Describe the sieves and sieve analysis. Forms and numbering screens (by the State Pharmacopoeia).

8. Fill in the table:

9. List the factors affecting the performance and efficiency of screening.

10. The hydraulic classification.

Fill in the table

11. The air separation. Design and operation of air separators. Pneumatic and gidroklassifikatory.

12. Application of the classification of materials in pharmaceutical technology.) - Briefly and in general terms,

13. Stirring solids. Definition.

a. The factors affecting the homogeneity of the mixture during preparation, transportation and storage of the powders.

b. on what grounds classify mixers solids.

14. Fill in the table: Comparative characteristics of mixers:

15. Moving and dosing of solid materials.

Fill in the table Conveyors:

16. Dosage solids by weight and volume. Dispensers manual, semi-automatic and automatic operation.

17. List what used moving and dosing of solid materials in pharmaceutical technology, provide examples.

D) Dosage form - powder. Fees

1. Powders.

a. Definition. Characteristics.

b. Classification of powder composition, dosage, use, method of prescribing the ingredients in the recipe.

c. Requirements powders.

d. Dispersible powders, depending on application.

e. Biopharmaceutical characterization of powders.

2. Make the technological and hardware circuits of powders in a pharmaceutical production.

3. Industrial, serial and small-scale production of powders. Nomenclature. Marking. Storage of the powders.

4. Features of the production of drugs for individual prescriptions. The recipe, its importance as a medical, technological economic and legal document. The structure of the recipe, and common rules for its completion. Making the finished product in accordance with the "Uniform rules of registration of medicines prepared in pharmacies." The structure and organization of work and production department retsepturno pharmacy.

5. Production of powders for individual prescriptions. Nomenclature.

a. List the basic rules of the mixing of the ingredients.

b. Particular cases of manufacturing powders.

c. Powders with potent and poisonous substances. Trituration.

6. Creation of a pharmacy aseptic manufacturing powders for injection, powders for wounds and burns surfaces for infants and children up to 1 year, with antimicrobial substances for introduction into the cavity.

7. Terms and Conditions of storage of powders. Particulars of powders with poisonous and narcotic substances.

8. Directions for powder: the use of semi-mechanized process, reduced water absorption, the use of new packaging materials, and others. The unification of the formulation and translation of powders or small-scale industrial production.

9. Evaluation of the quality powder: precision dosing, mixing uniformity, particle size, flowability, microbiological purity.

10. Fees.

a. Definition. Characteri

Additional information

b. Types of fees. Briquetted and pressed charges teas. Charges in the single-dose containers.

11. Technological scheme of production and hardware. Indicators of quality standardization.

12. Packing, packaging. Storage conditions and shelf life. The range of medical fees. Prospects for improving the formulation and technology.

13. Improving the technology of powders and fees in industrial production.

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